Major Neurocognitive Disorder is characterized by:

Major Neurocognitive Disorder, commonly referred to as dementia, is characterized by a significant decline in cognitive abilities that substantially impacts daily life and functioning. This disorder affects various cognitive domains, including memory, reasoning, attention, language, and the ability to perform complex tasks. When individuals experience a significant decline in these areas, it can hinder their ability to conduct everyday activities, manage personal care, make decisions, or maintain social relationships, leading to noticeable impairments in their quality of life.

The presence of substantial cognitive decline differentiates Major Neurocognitive Disorder from other conditions, such as Mild Neurocognitive Disorder, where the decline is not severe enough to interfere significantly with daily functioning. Therefore, the correct answer accurately reflects the severity and impact of the cognitive decline associated with Major Neurocognitive Disorder.